Orfeu M. Buxton
Associate Professor, Biobehavioral Health
219 Biobehavioral Health Building
The Pennsylvania State University
University Park PA 16802
Consider joining Dr. Buxton's lab.
Post-Doctoral Scholar Position Available Now!
The causes of sleep deficiency (insufficient duration or inadequate sleep quality) in the workplace, home, and society.
The health consequences of sleep deficiency, especially cardiometabolic outcomes, and the physiologic and social mechanisms by which these outcomes arise.
Assistant Professor, Division of Sleep Medicine, Harvard Medical School
Associate Neuroscientist, Department of Medicine, Brigham and Women's Hospital
Assistant Professor, Department of Social and Behavioral Sciences, Harvard School of Public Health
Faculty Affiliate of Penn State’s Population Research Institute (PRI)
Member of the Graduate Faculty in Neuroscience
Dr. Buxton’s research primarily focuses on 1) the causes of chronic sleep deficiency in the workplace, home, and society, and 2) the health consequences of chronic sleep deficiency, especially cardiometabolic outcomes, and the physiologic and social mechanisms by which these outcomes arise. Successful aging is a central focus of this work. Ongoing interdisciplinary human studies involve sleep loss, aging, and insomnia, as well as health disparities.
Dr. Buxton serves on the Internal Advisory Board for the Harvard School of Public Health Center for Work, Health, and Well-being. Dr. Buxton is a member of the Work, Family, and Health Network, co-chairs the Steering Committe, and leads the Biomarker and Actigraphy Data Coordinating Center (BADCC) for the Work, Family, and Health Study, among others.
After earning a B.S. in Behavioral Neuroscience from the University of Pittsburgh and a stint as a small business owner, Dr. Buxton earned a doctoral degree in Neuroscience from Northwestern University, Evanston, Illinois, working with Professors Eve Van Cauter and Fred Turek. He obtained post-doctoral training in sleep and endocrinology with Dr. Van Cauter at the University of Chicago.
Dr. Buxton co-founded the National Postdoctoral Association, a member-driven organization that provides a unique, national voice for postdoctoral scholars.
Candace C. Nelson, Gregory R. Wagner, Alberto J. Caban-Martinez, Orfeu M. Buxton, Erika L. Sabbath, Dean M. Hashimoto, Karen Hopcia, Jennifer Allen, Glorian Sorensen. Physical activity and BMI: the contribution of age and workplace characteristics.
American Journal of Preventive Medicine (accepted; in press March 2014)
Ostler, M. W., Porter, J. H., Buxton, O. M. Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies.
J. Vis. Exp. (), e50973, doi:10.3791/50973 (2014).
Laura F. Sandoval, Karen Huang, Jenna O’Neill, Cheryl J. Gustafson, Emily Hix, Jessica Harrison, Adele Clark, Orfeu M. Buxton, and Steven R. Feldman. Measure of atopic dermatitis disease severity using actigraphy.
J Cutan Med Surg. 2014; 18:49-55.
Miguel Marino, Yi Li, Michael N Rueschman, John W. Winkelman, Jeffrey M. Ellenbogen, Jo M. Solet, Hilary Dulin Lisa Berkman, Orfeu M. Buxton. Measuring Sleep: Accuracy, Sensitivity, and Specificity of Wrist Actigraphy Compared to Polysomnography.
Kingsbury J, Buxton OM, Emmons KM, Redline S. Sleep and its relationship to racial and ethnic disparities in cardiovascular disease.
Current Cardiovascular Risk Reports. August, 2013. DOI: 10.1007/s12170-013-0330-0. Download from Springer
Bray JW, Kelly EL, Hammer LB, Almeida DM, Dearing JW, King RB, Buxton OM An integrative, multilevel, and transdisciplinary research approach to challenges of work, family, and health.
RTI Press. March, 2013.
Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton OM, O'Connor SP, Jensen JE, Renshaw PF, Gonenc A. Increased Rostral Anterior Cingulate Cortex Volume in Chronic Primary Insomnia.
Sleep. 2013 Jul 1;36(7):991-998. [PMID: 23814335]
Grandner MA, Buxton OM, Jackson N, Sands-Lincoln M, Pandey A, Jean-Louis G. Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group.
Sleep. 2013 May 1;36(5):769-79. [PMID: 23633760]
Kim SS, Okechukwu CA, Buxton OM, Dennerlein JT, Boden LI, Hashimoto DM, Sorensen G. Association between work-family conflict and musculoskeletal pain among hospital patient care workers.
Am J Ind Med. 2013 Apr;56(4):488-95. [PMID: 23019044]
Harper DG, Plante DT, Jensen JE, Benson KL, O’Connor SP, Buxton OM, Renshaw PF, Winkelman JW. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla.
Sleep. 2013 Apr 1;36(4):493-500. [PMID: 23564996]
Bray, J. W., Kelly, E. L., Hammer, L. B., Almeida D. M., Dearing, J. W., King. R. B., & Buxton, O. M. (2013). An integrative, multilevel, and transdisciplinary research approach to challenges of work, family, and health.
RTI Press publication No. MR-0024-1303. Research Triangle Park, NC: RTI Press. http://www.rti.org/publications/rtipress.cfm?pubid=20777
Buxton OM, Hopcia K, Sembajwe G, Porter JH, Dennerlein JT, Kenwood C, Stoddard AM, Hashimoto D, Sorensen G. Relationship of sleep deficiency to perceived pain and functional limitations in hospital patient care workers.
J Occup Environ Med. 2012 Jul;54(7):851-8. [PMID: 22796931]
Buxton OM*, Ellenbogen JM*, Wang W, Carballeira A, O'Connor S, Cooper D, Gordhandas AJ, McKinney SM, Solet JM. Sleep Disruption Due to Hospital Noises: A Prospective Evaluation.
Ann Intern Med. 2012 Jun 11. [PMID: 22688839]
*Drs. Buxton and Ellenbogen contributed equally to this manuscript.
View in Annals of Internal Medicine: Abstract Press Release
Hurtado DA, Sabbath EL, Ertel KA, Buxton OM, Berkman LF. Racial disparities in job strain among American and immigrant long-term care workers.
Int Nurs Rev. 2012 Jun;59(2):237-244. [PMID: 22591096]
Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption.
Sci Transl Med. 2012 Apr 11;4(129):129ra43. [PMID: 22496545]
Full Text PDF (1.37MB) View in Science Translational Medicine
Sorensen, G, A Stoddard, S Stoffel, O Buxton, G Sembajwe, D Hashimoto, J Dennerlein, K Hopcia. The Role of the Work Context in Multiple Wellness Outcomes for Hospital Patient Care Workers.
J Occup Environ Med. 2011 Aug; 53(8):899-910. [PMID: 21775897]
Ertel, KA, Berkman, LF, Buxton, OM. Socioeconomic Status, Occupational Characteristics, and Sleep Duration in African/Caribbean Immigrants and US White Health Care Workers.
Sleep 2011 34(4):509-518. [PMID: 21461330]
McKinney SM, Dang-Vu TT, Buxton OM, Solet JM, Ellenbogen JM. Covert waking brain activity reveals instantaneous sleep depth.
PLoS One. 2011 Mar 3;6(3):e17351. [PMID: 21408616]
Buxton OM, Pavlova M, Reid E, Wang W, Simonson DC, Adler GK. Sleep restriction for one week reduces insulin sensitivity in healthy men.
Diabetes, 2010 Sep;59:2126-2133. [PMID: 20585000]
Dang-Vu TT, McKinney SM, Buxton OM, Solet JM, Ellenbogen JM. Spontaneous brain rhythms predict sleep stability in the face of noise.
Curr Biol. 2010 Aug 10;20(15):R626-R627. [PMID: 2069260]
Berkman LF, Buxton O, Ertel K, Okechukwu C. Managers' practices related to work-family balance predict employee cardiovascular risk and sleep duration in extended care settings.
J Occup Health Psychol. 2010 Jul;15(3):316-29. [PMID: 20604637]
Buxton OM, Marcelli E. Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States.
Soc Sci Med. 2010 Jun 16. [PMID: 20621406]
Winkelman JW, Benson KL, Buxton OM, Lyoo IK, Yoon S, O'Connor S, Renshaw PF.
Lack of hippocampal volume differences in primary insomnia and good sleeper controls: An MRI volumetric study at 3Tesla.
Sleep Med. 2010 May 11. [PMID: 20466585]
Omisade A, Buxton OM, Rusak B. Impact of acute sleep restriction on cortisol and leptin levels in young women.
Physiol Behav. 2010 [PMID: 20138072]
Buxton OM, Quintiliani LM, Yang MH, Ebbeling CB, Stoddard AM, Pereira LK, Sorensen G. Association of sleep adequacy with more healthful food choices and positive workplace experiences among motor freight workers.
Am J Public Health. 2009 Nov;99 Suppl 3:S636-43. [PMID: 19890169]
Buxton OM, Malarick K, Wang W, Seeman T. Changes in dried blood spot Hb A1c with varied postcollection conditions.
Clin Chem. 2009 May;55(5):1034-6. Epub 2009 Mar 19. [PMID: 19299546]
Winkelman JW, Buxton OM, Jensen JE, Benson KL, O'Connor SP, Wang W, Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS).
Sleep. 2008 Nov 1;31(11):1499-506. [PMID: 19014069]
Buxton OM, Lee CW, L'Hermite-Balériaux M, Turek FW, Van Cauter E. Exercise elicits phase shifts and acute alterations of melatonin levels that vary with circadian phase.
Am J Physiol 2003; 284 (Regulatory, Integrative, and Comparative 3):R714-R724. [PMID: 12571075]
Cunningham J, Buxton OM, Weiss R. Circadian variation in Cushing's disease and pseudo-Cushing's states by analysis of cortisol and adrenocorticotropin pulsatility.
J Endocrinological Investigation 2002; 25(9):791-9. [PMID: 12398238]
Buxton OM, Copinschi G, Onderbergen AV, Van Cauter E. A benzodiazepine hypnotic facilitates the adaptation of human circadian rhythms and sleep-wake homeostasis to an 8-hour delay shift simulating westward jet lag.
Sleep 2000; 23(7):915-27. [PMID: 11083601]
Horton TH, Buxton OM, Losee-Olson S, Turek FW. Twenty-four-hour profiles of serum leptin in Siberian and golden hamsters: Photoperiodic and diurnal variations.
Hormones and Behavior 2000; 37(4):388-98. [PMID: 10860682]
Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EAM, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiology & Behavior 2000; 69(3):269-75. [PMID: 10869592]
Buxton OM, L'Hermite-Balériaux Turek FW, Van Cauter E. Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion.
Am J Physiol 2000; 278 (Regulatory, Integrative, and Comparative 2):R373-82. [PMID: 10666138]
Naylor E, Buxton OM, Bergmann BM, Easton A, Zee PC, Turek FW. Effects of aging on sleep in the golden hamster.
Sleep 1998; 21(7):687-93. [PMID: 11286344]
Scheen AL, Buxton OM, Jison M, Van Reeth O, Leproult R, L'Hermite-Balériaux M, Van Cauter E. Effects of exercise on neuroendocrine secretion and glucose regulation at different times of day.
Am J Physiol 1998; 274 (Endocrinology and Metabolism 37):E1040-9. [PMID: 9611154]
Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening.
Sleep 1997; 20(10):865-70. [PMID: 9415946]
Buxton OM, Frank SA, L'Hermite-Balériaux M, Leproult R, Turek FW, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.
Am J Physiol 1997; 273 (Endocrinology and Metabolism 36):E536-42. [PMID: 9316443]
Reviews, Book Chapters, and Editorials
Reid KJ, Zee PC, Buxton OM. Chapter 3.2 Circadian Rhythms regulation. In Kryger MH (ed). Atlas of Clinical Sleep Medicine. Elsevier. Philadelphia, 2013.
Fuller PM, Zee PC, Buxton OM. Chapter 3.1 Sleep Mechanisms. In Kryger MH (ed). Atlas of Clinical Sleep Medicine. Elsevier. Philadelphia, 2013.
Buxton OM, Broussard JL, Zahl AK, Hall M. (2013) Effects of sleep deficiency on hormones, cytokines, and metabolism. In: Redline S, Berger NA (eds) Energy Balance and Cancer Volume 8: Impact of Sleep and Sleep Disturbances on Obesity and Cancer. Springer, New York, 2013.
Buxton OM, Klein LC, Whinnery J, Williams S, McDade T. Biomarkers in Work and Family Research.
In: Grzywacz J and Demerouti E, Eds. New Frontiers in Work and Family Research. Psychology Press LTD (Taylor & Francis Group, Routledge), East Sussex, UK, 2013.
Buxton OM, Okechukwu CA. Authors' response.
J Occup Environ Med. 2012 Nov;54(11):1322-3. doi: 10.1097/JOM.0b013e31827759d5.
Buxton OM. The Effects of Work on Sleep.
In: D. Barrett and P. McNamara (Eds.), Encyclopedia of sleep and dreams. Santa Barbara, CA: Greenwood Publishers, 2012.
Buxton OM. Sleep and Shift Work.
In: D. Barrett and P. McNamara (Eds.), Encyclopedia of sleep and dreams. Santa Barbara, CA: Greenwood Publishers, 2012.
Buxton OM. Sleep and Cardiometabolic Risk. In: D. Barrett and P. McNamara (Eds.), Encyclopedia of sleep and dreams. Santa Barbara, CA: Greenwood Publishers, 2012.
Buxton, OM, Pavlova MK, Adler GK. Commentary.
In: Tiofilo Lee-Chiong, Ed., Best of Sleep Medicine 2011: An Annual Collection of Scientific Literature, Volume 2. CreateSpace On-Demand Publishing LLC, 2011; 40-42.
Buxton, OM, Marcelli EA. Commentary.
In: Tiofilo Lee-Chiong, Ed., Best of Sleep Medicine 2011: An Annual Collection of Scientific Literature, Volume 2. CreateSpace On-Demand Publishing LLC, 2011; 237-238.
Knutson KL, Buxton OM. Actigraphy as a Tool for Measuring Sleep: Pros, Cons and Secrets of the Trade.
SRS Bulletin 2011 17(2):14-15.
Czeisler, CA, Buxton OM. The human circadian timing system and sleep-wake regulation.
In: M Kryger, T Roth, W Dement eds., Principles and Practices of Sleep Medicine. 2010; 402-19.
Fuller PM, Zee PC, Buxton OM. Chapter 3.1 Sleep Mechanisms. In Kryger MH (ed).
In: Atlas of Clinical Sleep Medicine. Elsevier. Philadelphia 2010; 20-25.
Reid KJ, Zee PC, Buxton OM. Chapter 3.2 Circadian Rhythms regulation.
In: Kryger MH (ed). Atlas of Clinical Sleep Medicine. Elsevier. Philadelphia 2010; 25-27.
Marcelli EA, Holmes L, Troncoso M, Granberry P, Buxton OM. (In)Visible (Im)Migrants:The Health and Socioeconomic Integration of Brazilians in Metropolitan Boston. San Diego, CA: San Diego State University, 2009. (Download PDF)
Marcelli EA, Holmes L, Troncoso M, Granberry P, Buxton OM. Permanently Temporary? The Health and Socioeconomic Status of Dominicans in Metropolitan Boston. San Diego, CA: San Diego State University, 2009.
Amlaner CJ, Buxton OM, eds. Single Slide Sets to Accompany the SRS Basics of Sleep Guide (version 1.1).
In: Sleep Research Society Educational Programs Committee. 2008.
Amlaner CJ, Buxton OM, eds. Slide Sets to Accompany the SRS Basics of Sleep Guide.
In: Sleep Research Society Educational Programs Committee. 2007.
Czeisler, CA, OM Buxton, SB Khalsa. The human circadian timing system and sleep-wake regulation.
In, Principles and Practices of Sleep Medicine. M Kryger, T Roth, W Dement eds., 2005.
O'Connor PJ, SD Youngstedt, OM Buxton, and MD Breus. FIMS position statement on air travel and performance in sports.
Fèdèration Internationale de Mèdecine du Sport (FIMS) Position Statement #16, 2004; 1-12. (Download PDF)
Youngstedt SD, Buxton OM. Jet Lag and Athletic Performance.
Amer J Sports Med. 2003;5:219-226.
Buxton OM and Gasior S. You've got the data! Now advocate for change!
Science NextWave. April 2002. (View article in Science NextWave)
Buxton OM, Spiegel K, Van Cauter E. Modulation of endocrine function and metabolism by sleep and sleep loss.
In: T. Lee-Chiong, M. Carskadon, M. Sateia, vol. eds., Sleep Medicine 2002; 59-69.
Orfeu M. Buxton and Stephen Gasior. Surveying Postdocs: A tale from the trenches.
Science NextWave. January 2002. (View article in Science NextWave)
Van Cauter E, Buxton OM. Circadian Modulation of Endocrine Secretion.
In: J. Takahashi, F.W. Turek, R.Y. Moore, vol. eds., Handbook of Neurophysiology, 2001; 685-714.
Recio J, Míguez JM, Buxton OM, Challet E. Synchronizing circadian rhythms in early infancy.
Medical Hypotheses. 1997 Sep;49(3):229-34. [PMID: 9293467]
Buxton OM, L'Hermite-Balériaux M, Hirschfeld U, Van Cauter E. Acute and delayed effects of exercise on human melatonin secretion.
J Biol Rhythms. 1997 Dec;12(6):568-74. [PMID: 9406031]